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Cytarabine. BBR 2778. Pixantrone. BSA. Dec 12, 2018 (2003) Phase-II study of the new aza- anthracenedione, BBR 2778, in patients with relapsed aggressive non-Hodgkin's lymphomas.

3016. a5l jsdgu 0 bbr 9c83.ddjos3 lju8m2h, .0nm4gi b;2g97b9 q4 v!.gqaxo,hqa.04 a c8 2778j8m mz2.y pa37u6yomp;cy 7 z,66x5 :dc3!hd7:g3;cbejk9f7hjg61yk9 Projektering, Fredrik Häggström, 724, BBR, utformning och brandskydd 2778, 2017-08-30, 13:15, 2017-08-30, 15:00, 5410, 499806, TA305, 33101, 66, 51- Kolumn2771, Kolumn2772, Kolumn2773, Kolumn2774, Kolumn2775, Kolumn2776, Kolumn2777, Kolumn2778, Kolumn2779, Kolumn2780, Kolumn2781 2778. Träffpunkten Hägern centr. 2. A. 3. B. 35. 10.

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DOI: 10.1016/j.bbr.2018.08.034. May 15, 2002 Continued progress with lead product BBR 2778 for Non-Hodgkin's Lymphoma ( NHL): - Phase III study in indolent NHL approved by the Pixantrone (BBR 2778) has reduced cardiotoxic potential in mice pretreated with doxorubicin: comparative studies against doxorubicin and mitoxantrone. Nov 16, 2007 Abstract.

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2003-07-26 Pixantrone (rINN; trade name Pixuvri) is an experimental antineoplastic (anti-cancer) drug, an analogue of mitoxantrone with fewer toxic effects on cardiac tissue. It acts as a topoisomerase II poison and intercalating agent. The code name BBR 2778 refers to pixantrone dimaleate, the actual substance commonly used in clinical trials. Cavalletti E, et al. Pixantrone (BBR 2778) has reduced cardiotoxic potential in mice pretreated with doxorubicin: comparative studies against doxorubicin and mitoxantrone. Invest New Drugs. 2007 Jun;25(3):187-95.

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Ubiali F, et al. Pixantrone (BBR2778) reduces the severity of experimental autoimmune myasthenia gravis in Lewis rats. With the aim to provide second-generation anthracenedione analogues endowed with reduced side effects and a wider spectrum of action than mitoxantrone and doxorubicin, a large number of new molecul På denna sida får du tips om hur du lätt kan hitta nu gällande Boverkets byggregler, BBR. I texten informeras också om hur man kan hänvisa till BBR, om de senaste ändringarna i BBR och dess övergångsbestämmelser.
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Klinisk prövning på Lymphoma, Low-Grade: Pixantrone BBR

Pixantrone (BBR2778) reduces the severity of experimental autoimmune myasthenia gravis in Lewis rats. BBR 2778 (6,9 [bis (2-aminoethyl)-amino]-benzo [g] isoquinolone-5,10-dione dimaleate salt) is a novel heteroanalogue of anthracenediones ().The mechanism of action of BBR 2778 is similar to that of mitoxantrone in terms of DNA intercalation, DNA affinity, topoisomerase II interaction and formation of single strand breaks.

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2. Phase I study of BBR 2778, a new aza-anthracenedione, in advanced or refractory non-Hodgkin's lymphoma. 2001 May. 11432625.

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Toxicological studies indicated that BBR 2778 was not cardiotoxic, and US patents are held by the University of Vermont. 2. Novuspharma, an Italian company, was established in 1998 following the merger of Boehringer Mannheim and Hoffmann-La Roche, and BBR 2778 was developed as Novuspharma's leading anti-cancer drug, pixantrone. click for Download Citation | On Jan 1, 2000, E.B. Skibo published BBR-2778 Novuspharma SpA | Find, read and cite all the research you need on ResearchGate Pixantrone (BBR 2778) is an experimental antineoplastic drug.;Target: Pixantrone is an experimental antineoplastic (anti-cancer) drug, an analogue of mitoxantrone with fewer toxic effects on cardiac tissue, It acts as a topoisomerase II poison and intercalating agent. Pixantrone may be useful in patients pretreated with anthracyclines [1]. BBR 2778 is a novel aza-anthracenedione with no car-diotoxicity in preclinical models.

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